Lucasarts just announced a brand new third-person shooter in collaboration with Day 1 Studios. Titled Fracture, the shooter is set in America in the year 2161, and is supposed to integrate highly destructive environments into its gameplay. The story involves an East vs West divide along the Mississippi, with mutants on one half and cybernetically enhanced humans on the other. Now, everybody knows that cyborgs and mutants hate each other, so of course, conflict is natural.
As Joystiq points out, the whole 'destructive environments' thing is something we've heard many times before and it has never really been delivered. I loved the Red Faction series myself - but I always thought it was odd how the second one actually toned down the destructive environments. I liked taking down whole bridges with people on them. It was fun.